Warning: Science Content!
For those of you who are not familiar with my research (which most likely includes everybody), perhaps I should explain the basis of my research:
Myometrium, the smooth muscle portion of the uterus, is responsible for the contractions during labor and delivery that result in childbirth. It is active only for a short time at the end of gestation and must remain in a relaxed (or quiescent) state for most of pregnancy.
A number of factors are able to affect the contractility of myometrium and consequently, control the timing and progression of labor. One of these factors is the access the myometrium has to oxygen. When we expose pregnant animals to low oxygen conditions, e.g. high altitude, we expect that the stress of long-term hypoxia (LTH) would cause the animals to be more prone to preterm labor. However, this is not the case. For instance, LTH can delay parturition (delivery) in rats for up to 1.5 days, significant when your pregnancy only lasts 21 days. Also, our lab has found that sheep exhibit reduced myometrial function when exposed to LTH. This seems to be an adaptation that decreases the likelihood of preterm birth.
In fact, my work has discovered two adaptations within the myometrial cell. First, calcium, which directly triggers contractions, is handled differently. We have found that the cell shifts its dependence from intracellular stores of calcium (in the sarcoplasmic reticulum) to extracellular stores (through L-type calcium channels). You can read more about it here.
We have also found that potassium channels, which dampen the excitability of the cell membrane, are altered. The activity of a key potassium channel called the BK channel is elevated. We are currently measuring the protein levels of this channel in the myometrium.We have also examined levels of another protein, called protein kinase G, that may potentially link these cellular pathways together.
Perhaps the greatest lesson that I will take away from my time in research is a deeper appreciation for the divine Author who designed these physiological systems. As I have studied physiology (the study of organismal function, as one of my professors defines it), I never cease to be amazed at the incredible complexity yet simple beauty of the Creator's handiwork. Although many of my professors believe in evolution, my research has actually strengthened my belief in a Creator God.
I will praise thee; for I am fearfully and wonderfully made: marvellous are thy works; and that my soul knoweth right well. Psalms 139:14It is my hope and prayer that my PhD will enable me to bring glory to my Creator (Rev 14:7) and hasten His soon return to make all things new (Rev 21:5).
9 Comments:
Thanks, Tim, for the informative summary of your research. Praise be to God for the greatest lesson you have learned that such research has directed you to the Source of all knowledge and truth!
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Hey Tim, thanks for the comment. Wow, man! That's some pretty good research you're doing. Keep it very simple, but deep, so that even a child (like myself!) can understand. But it sounds like you're on that track. Next time you come around to Andrews, gimme a call! God bless.
Thanks for sharing. I think I actually understand what you're talking about!
Amen, Tim! God bless you.
Wow...
I actually read the entire thing. ;)
How very, very interesting...
I can only imagine that as you study and discover more about the vastness within even cells you're led to praise our Creator for his intricate handiwork...
Your poster looked great too...good work. =)
I also do hope that through your PhD you can glorify the Creator Who designed you with a specific plan in mind. ^^
Have a good weekend!
Good info. Now I know what you do!
Enjoyed reading your Science Content! also appreciate the simplicity... I finally have a clearer understanding of what you are researching! I am also spiritually uplifted by your testimony... to God be the glory indeed. Thank you and God bless. ei
Tim:
I am fascinated by your myometrial and PTL research. Have you checked the human gestational period for the inhabitants of the Peruvian Andes? I wonder if its longer than 40 weeks. What about hypoxemia in smokers?
I suppose there a million other questions to ask based on your discoveries. Keep up the good work.
Loved having your parents visit here and show us all about Tim.
Doctor Uncle K.
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